The world health organization has described obesity as one of today�s most neglected public health problems,\r\naffecting every region of the globe. The present study was planned to evaluate antiobesity activity of Hippophae rhamnoides L.\r\nseeds in MSG induced-obese mice. Hydro alcoholic extract of Hippophae rhamnoides L. seeds (HEHS) (286 and 667 mg.kg-1.d-1)\r\nor vehicle control treatment was given orally once a day for 56 days to MSG induced-obese mice. Food intake, water intake,\r\ngrowth curve, body weight, total body fat and other biochemical parameter evaluated. Lipid profile and glucose were quantified\r\nat the start (t = 0), 14, 28, 42 and 56 days after the administration of the extract whereas plasma insulin, adiponectin and leptin\r\nwere assessed at the end of the experimental protocol. After 56 days HEHS treatment, it could effectively lower the body weight\r\nand total body fat content and significantly flattened (P<0.05) adiposity index of MSG-induced obese mice as compared with\r\nuntreated MSG-induced obese mice. HEHS also the significantly decreased plasma levels of triglyceride, total cholesterol, leptin\r\nand insulin whereas increased adeponectin level as compare to MSG control group. In conclusion, HEHS showed a potential antiobesity\r\neffect in MSG-induced mice, which may be mediated by altering plasma peripheral peptides level particularly leptin,\r\ninsulin and adeponectin with body fat distribution. Even though, more studies are needed to support this promising mechanism\r\nand chemical constitute responsible for its anti-obesity effect.
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